Decreased Hemojuvelin Protein Levels in Mask Mice Lacking Matriptase-2-Dependent Proteolytic Activity
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چکیده
منابع مشابه
Decreased hemojuvelin protein levels in mask mice lacking matriptase-2-dependent proteolytic activity.
Matriptase-2, a membrane protein encoded by the Tmprss6 gene, is a negative regulator of hepcidin expression. Although matriptase-2 has been proposed to cleave membrane hemojuvelin, we have recently found decreased hemojuvelin protein levels in Tmprss6 -/- mice. The purpose of this study was to confirm this observation by determining hemojuvelin protein levels in another strain of mice with dis...
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متن کاملMatriptase shedding is closely coupled with matriptase zymogen activation and requires de novo proteolytic cleavage likely involving its own activity
The type 2 transmembrane serine protease matriptase is involved in many pathophysiological processes probably via its enzymatic activity, which depends on the dynamic relationship between zymogen activation and protease inhibition. Matriptase shedding can prolong the life of enzymatically active matriptase and increase accessibility to substrates. We show here that matriptase shedding occurs vi...
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ژورنال
عنوان ژورنال: Physiological Research
سال: 2013
ISSN: 1802-9973,0862-8408
DOI: 10.33549/physiolres.932455